Assay Detail
Binding
CHEMBL671129
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Binding affinity against dopamine receptor D2
71
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Enhanced D1 affinity in a series of piperazine ring substituted 1-piperazino-3-arylindans with potential atypical antipsychotic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 71 | 7.40 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136340 | — | — | 1 | 8.52 |
| CHEMBL136260 | — | — | 3 | 8.51 |
| CHEMBL343922 | — | — | 3 | 8.35 |
| CHEMBL140189 | — | — | 1 | 8.32 |
| CHEMBL136630 | — | — | 3 | 8.30 |
| CHEMBL136822 | — | — | 2 | 8.30 |
| CHEMBL136648 | — | — | 1 | 8.28 |
| CHEMBL140032 | — | — | 1 | 8.25 |
| CHEMBL343078 | — | — | 1 | 8.24 |
| CHEMBL136226 | — | — | 1 | 8.21 |
| CHEMBL344206 | — | — | 1 | 8.20 |
| CHEMBL136235 | — | — | 3 | 8.17 |
| CHEMBL343282 | — | — | 3 | 8.15 |
| CHEMBL136683 | — | — | 3 | 8.14 |
| CHEMBL137430 | — | — | 1 | 8.09 |
| CHEMBL136776 | — | — | 1 | 8.07 |
| CHEMBL137960 | — | — | 3 | 8.02 |
| CHEMBL12628 | — | — | 1 | 8.00 |
| CHEMBL335155 | — | — | 1 | 7.96 |
| CHEMBL136722 | — | — | 3 | 7.92 |
| CHEMBL2111937 | — | — | 1 | 7.92 |
| CHEMBL344216 | — | — | 1 | 7.92 |
| CHEMBL337542 | — | — | 1 | 7.89 |
| CHEMBL136480 | — | — | 1 | 7.89 |
| CHEMBL136262 | — | — | 1 | 7.85 |
| CHEMBL422067 | — | — | 1 | 7.70 |
| CHEMBL136932 | — | — | 1 | 7.68 |
| CHEMBL137954 | — | — | 1 | 7.64 |
| CHEMBL344426 | — | — | 1 | 7.62 |
| CHEMBL307717 | — | — | 3 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136340 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL136260 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL343922 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL140189 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL136260 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL136822 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL136630 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL136648 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL140032 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL343078 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL136226 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL344206 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL136235 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL343282 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL136683 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL343282 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL137430 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL136776 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL136683 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL137960 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL12628 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL343922 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL136235 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL335155 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL344216 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2111937 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL136722 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL136480 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL337542 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL136822 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL136262 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL137960 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL422067 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL343922 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL136932 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL137954 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL344426 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL136630 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL136722 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL307717 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL136468 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL137805 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL342698 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL139304 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL96618 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL138964 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL136553 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL139258 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL137536 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL136562 | — | IC50 | = | 82.0 | nM | 7.09 |