Assay Detail
Binding
CHEMBL617461
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Binding affinity for 5-hydroxytryptamine 2A receptor, activity is expressed as IC50 values.
33
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Enhanced D1 affinity in a series of piperazine ring substituted 1-piperazino-3-arylindans with potential atypical antipsychotic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.97 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343282 | — | — | 3 | 9.00 |
| CHEMBL136630 | — | — | 2 | 8.96 |
| CHEMBL140032 | — | — | 1 | 8.82 |
| CHEMBL136226 | — | — | 1 | 8.77 |
| CHEMBL136235 | — | — | 3 | 8.72 |
| CHEMBL136722 | — | — | 3 | 8.54 |
| CHEMBL136776 | — | — | 1 | 8.52 |
| CHEMBL136683 | — | — | 3 | 8.49 |
| CHEMBL137960 | — | — | 3 | 8.49 |
| CHEMBL140189 | — | — | 1 | 8.47 |
| CHEMBL343078 | — | — | 1 | 8.35 |
| CHEMBL136648 | — | — | 1 | 8.12 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.11 |
| CHEMBL136891 | — | — | 1 | 8.03 |
| CHEMBL137536 | — | — | 1 | 8.01 |
| CHEMBL136190 | — | — | 1 | 7.85 |
| CHEMBL136468 | — | — | 1 | 7.68 |
| CHEMBL344680 | — | — | 1 | 7.68 |
| CHEMBL136873 | — | — | 1 | 7.58 |
| CHEMBL138964 | — | — | 1 | 7.54 |
| CHEMBL136334 | — | — | 1 | 7.51 |
| CHEMBL139258 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343282 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL136630 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL140032 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL136226 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL136235 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL343282 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL136630 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL136722 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL136776 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL137960 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL136683 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL140189 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL136235 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL136683 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL137960 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL343078 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL136722 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL136648 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL136891 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL137536 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL136190 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL136468 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL344680 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL136873 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL138964 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL136334 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL139258 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL137960 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL136235 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL136722 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL343282 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL136683 | — | IC50 | = | 3600.0 | nM | 5.44 |