Assay Detail
Binding
CHEMBL644807
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Compound was tested for inhibition of Adenosine transporter P2 type by using [2-3H]adenosine as radioligand in Trypanosoma equiperdum
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma equiperdum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and uptake of nitric oxide-releasing drugs by the P2 nucleoside transporter in Trypanosoma equiperdum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.70 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29507 | — | — | 1 | 6.70 |
| CHEMBL27357 | — | — | 1 | 6.24 |
| CHEMBL287449 | — | — | 1 | 6.21 |
| CHEMBL26220 | — | — | 1 | 5.72 |
| CHEMBL605462 | — | — | 1 | 5.46 |
| CHEMBL2205239 | — | — | 1 | 4.91 |
| CHEMBL1650564 | CYMELARSEN | — | 1 | 4.64 |
| CHEMBL27352 | — | — | 1 | - |
| CHEMBL25961 | — | — | 1 | - |
| CHEMBL26029 | — | — | 1 | - |
| CHEMBL73188 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29507 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL27357 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL287449 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL26220 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL605462 | — | Ki | = | 3470.0 | nM | 5.46 |
| CHEMBL2205239 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL1650564 | CYMELARSEN | Ki | = | 22900.0 | nM | 4.64 |
| CHEMBL27352 | — | Ki | = | 404000.0 | nM | - |
| CHEMBL25961 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL26029 | — | Ki | = | 117000.0 | nM | - |
| CHEMBL73188 | — | Ki | > | 1000000.0 | nM | - |