Assay Detail
Binding
CHEMBL645102
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Evaluated for its ability to displace [3H]prazosin from alpha-1-Adrenoceptor of calf cerebral cortex
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.35 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48603 | — | — | 1 | 6.96 |
| CHEMBL48558 | — | — | 1 | 6.68 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 6.66 |
| CHEMBL299595 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48603 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL48558 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL299595 | — | Ki | = | 8000.0 | nM | 5.10 |