Assay Detail
Functional
CHEMBL645252
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aorta
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Angiotensin analogues palmitoylated in positions 1 and 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.85 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268804 | — | — | 1 | 8.10 |
| CHEMBL264230 | — | — | 1 | 6.99 |
| CHEMBL384349 | — | — | 1 | 6.99 |
| CHEMBL411624 | — | — | 1 | 5.31 |
| CHEMBL402669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268804 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL264230 | — | Kd | = | 102.33 | nM | 6.99 |
| CHEMBL384349 | — | Kd | = | 102.33 | nM | 6.99 |
| CHEMBL411624 | — | Kd | = | 4897.79 | nM | 5.31 |
| CHEMBL402669 | — | Kd | > | 3162.28 | nM | - |