Assay Detail
Binding
CHEMBL645254
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pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Synthesis and In Vitro evaluation of fused ring heterocyle-containing angiotensin II antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 40 | 7.72 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416477 | — | — | 1 | 10.30 |
| CHEMBL49410 | — | — | 1 | 9.93 |
| CHEMBL49663 | — | — | 1 | 8.59 |
| CHEMBL299741 | — | — | 1 | 8.58 |
| CHEMBL48270 | — | — | 1 | 8.53 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.43 |
| CHEMBL49528 | — | — | 1 | 8.29 |
| CHEMBL48799 | — | — | 1 | 8.19 |
| CHEMBL46391 | — | — | 1 | 8.17 |
| CHEMBL46433 | — | — | 1 | 8.14 |
| CHEMBL52036 | — | — | 1 | 8.11 |
| CHEMBL300194 | — | — | 1 | 8.08 |
| CHEMBL50174 | — | — | 1 | 8.07 |
| CHEMBL295498 | — | — | 1 | 8.03 |
| CHEMBL49715 | — | — | 1 | 8.02 |
| CHEMBL301819 | — | — | 1 | 7.97 |
| CHEMBL46392 | — | — | 1 | 7.92 |
| CHEMBL300438 | — | — | 1 | 7.53 |
| CHEMBL50109 | — | — | 1 | 7.52 |
| CHEMBL448727 | — | — | 1 | 7.45 |
| CHEMBL51987 | — | — | 1 | 7.38 |
| CHEMBL49952 | — | — | 1 | 7.32 |
| CHEMBL49573 | — | — | 1 | 7.32 |
| CHEMBL295935 | — | — | 1 | 7.14 |
| CHEMBL50007 | — | — | 1 | 7.13 |
| CHEMBL417910 | — | — | 1 | 7.06 |
| CHEMBL422050 | — | — | 1 | 7.01 |
| CHEMBL48868 | — | — | 1 | 6.97 |
| CHEMBL48145 | — | — | 1 | 6.94 |
| CHEMBL49587 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416477 | — | Kd | = | 0.05012 | nM | 10.30 |
| CHEMBL49410 | — | Kd | = | 0.1175 | nM | 9.93 |
| CHEMBL49663 | — | Kd | = | 2.57 | nM | 8.59 |
| CHEMBL299741 | — | Kd | = | 2.63 | nM | 8.58 |
| CHEMBL48270 | — | Kd | = | 2.951 | nM | 8.53 |
| CHEMBL191 | LOSARTAN | Kd | = | 3.715 | nM | 8.43 |
| CHEMBL49528 | — | Kd | = | 5.129 | nM | 8.29 |
| CHEMBL48799 | — | Kd | = | 6.457 | nM | 8.19 |
| CHEMBL46391 | — | Kd | = | 6.761 | nM | 8.17 |
| CHEMBL46433 | — | Kd | = | 7.244 | nM | 8.14 |
| CHEMBL52036 | — | Kd | = | 7.762 | nM | 8.11 |
| CHEMBL300194 | — | Kd | = | 8.318 | nM | 8.08 |
| CHEMBL50174 | — | Kd | = | 8.511 | nM | 8.07 |
| CHEMBL295498 | — | Kd | = | 9.333 | nM | 8.03 |
| CHEMBL49715 | — | Kd | = | 9.55 | nM | 8.02 |
| CHEMBL301819 | — | Kd | = | 10.72 | nM | 7.97 |
| CHEMBL46392 | — | Kd | = | 12.02 | nM | 7.92 |
| CHEMBL300438 | — | Kd | = | 29.51 | nM | 7.53 |
| CHEMBL50109 | — | Kd | = | 30.2 | nM | 7.52 |
| CHEMBL448727 | — | Kd | = | 35.48 | nM | 7.45 |
| CHEMBL51987 | — | Kd | = | 41.69 | nM | 7.38 |
| CHEMBL49573 | — | Kd | = | 47.86 | nM | 7.32 |
| CHEMBL49952 | — | Kd | = | 47.86 | nM | 7.32 |
| CHEMBL295935 | — | Kd | = | 72.44 | nM | 7.14 |
| CHEMBL50007 | — | Kd | = | 74.13 | nM | 7.13 |
| CHEMBL417910 | — | Kd | = | 87.1 | nM | 7.06 |
| CHEMBL422050 | — | Kd | = | 97.72 | nM | 7.01 |
| CHEMBL48868 | — | Kd | = | 107.15 | nM | 6.97 |
| CHEMBL48145 | — | Kd | = | 114.82 | nM | 6.94 |
| CHEMBL49587 | — | Kd | = | 138.04 | nM | 6.86 |
| CHEMBL49294 | — | Kd | = | 151.36 | nM | 6.82 |
| CHEMBL48400 | — | Kd | = | 338.84 | nM | 6.47 |
| CHEMBL49848 | — | Kd | = | 776.25 | nM | 6.11 |
| CHEMBL48259 | — | Kd | = | 933.25 | nM | 6.03 |
| CHEMBL48606 | — | Kd | > | 100.0 | nM | - |
| CHEMBL299608 | — | Kd | > | 100.0 | nM | - |
| CHEMBL48511 | — | Kd | > | 100.0 | nM | - |
| CHEMBL421865 | — | Kd | > | 100.0 | nM | - |
| CHEMBL50417 | — | Kd | > | 100.0 | nM | - |
| CHEMBL52053 | — | Kd | > | 100.0 | nM | - |