Assay Detail
Binding
CHEMBL645373
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Effective concentration as Adenylate cyclase activity was measured in rat homogenate
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.99 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320428 | — | — | 1 | 8.00 |
| CHEMBL318338 | — | — | 1 | 8.00 |
| CHEMBL319707 | — | — | 1 | 6.94 |
| CHEMBL106801 | — | — | 1 | 6.89 |
| CHEMBL104772 | — | — | 1 | 6.87 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 6.85 |
| CHEMBL106836 | — | — | 1 | 6.83 |
| CHEMBL106116 | — | — | 1 | 6.82 |
| CHEMBL104141 | — | — | 1 | 6.48 |
| CHEMBL104571 | — | — | 1 | 6.21 |
| CHEMBL299161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320428 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL318338 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL319707 | — | EC50 | = | 114.0 | nM | 6.94 |
| CHEMBL106801 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL104772 | — | EC50 | = | 134.0 | nM | 6.87 |
| CHEMBL25856 | DIHYDREXIDINE | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL106836 | — | EC50 | = | 148.0 | nM | 6.83 |
| CHEMBL106116 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL104141 | — | EC50 | = | 333.0 | nM | 6.48 |
| CHEMBL104571 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL299161 | — | EC50 | > | 10.0 | nM | - |