Assay Detail
Functional
CHEMBL645500
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Functional activity at Adenosine A2A receptor as vasorelaxation of rat aorta
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-[N'-(3-arylallylidene)hydrazino]adenosines showing A2a adenosine agonist properties and vasodilation activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.36 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331372 | CGS-21680 | — | 1 | 6.94 |
| CHEMBL2113564 | — | — | 1 | 6.71 |
| CHEMBL2113563 | — | — | 1 | 6.57 |
| CHEMBL2113559 | — | — | 1 | 6.55 |
| CHEMBL464859 | NECA | — | 1 | 6.41 |
| CHEMBL2113556 | — | — | 1 | 6.32 |
| CHEMBL2113554 | — | — | 1 | 6.28 |
| CHEMBL2113558 | — | — | 1 | 6.20 |
| CHEMBL2113560 | — | — | 1 | 6.17 |
| CHEMBL2113552 | — | — | 1 | 6.15 |
| CHEMBL2113553 | — | — | 1 | 6.14 |
| CHEMBL611571 | — | — | 1 | 6.13 |
| CHEMBL2113555 | — | — | 1 | 6.10 |
| CHEMBL284969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331372 | CGS-21680 | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL2113564 | — | EC50 | = | 195.0 | nM | 6.71 |
| CHEMBL2113563 | — | EC50 | = | 269.0 | nM | 6.57 |
| CHEMBL2113559 | — | EC50 | = | 281.0 | nM | 6.55 |
| CHEMBL464859 | NECA | EC50 | = | 394.0 | nM | 6.41 |
| CHEMBL2113556 | — | EC50 | = | 482.0 | nM | 6.32 |
| CHEMBL2113554 | — | EC50 | = | 529.0 | nM | 6.28 |
| CHEMBL2113558 | — | EC50 | = | 638.0 | nM | 6.20 |
| CHEMBL2113560 | — | EC50 | = | 677.0 | nM | 6.17 |
| CHEMBL2113552 | — | EC50 | = | 704.0 | nM | 6.15 |
| CHEMBL2113553 | — | EC50 | = | 728.0 | nM | 6.14 |
| CHEMBL611571 | — | EC50 | = | 747.0 | nM | 6.13 |
| CHEMBL2113555 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL284969 | — | EC50 | > | 10000.0 | nM | - |