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Assay Detail

CHEMBL645501

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Functional activity against A2a adenosine receptor from rat aorta.
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Adenosine receptor A2a (CHEMBL302)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists.
Cristalli G, Camaioni E, Vittori S, Volpini R, Borea PA, Conti A, Dionisotti S, Ongini E, Monopoli A.
J Med Chem (1995) 38 : 1462 -1472
PubMed 7739005 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 6.64 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL604649 1 6.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL604649 EC50 = 227.0 nM 6.64