Assay Detail
Binding
CHEMBL645548
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Binding of [3H]prazosin to alpha-1 adrenergic receptor of rat cerebral cortical membranes
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Syntheses of (R)- and (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: effect of stereochemistry on fluorine-induced adrenergic selectivities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.33 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL679 | EPINEPHRINE | 4.0 | 2 | 5.80 |
| CHEMBL40986 | — | — | 1 | 5.60 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 2 | 5.52 |
| CHEMBL40317 | — | — | 1 | 5.43 |
| CHEMBL42359 | — | — | 1 | 5.30 |
| CHEMBL41818 | — | — | 1 | 5.22 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 4.85 |
| CHEMBL40268 | — | — | 1 | 4.80 |
| CHEMBL295651 | — | — | 1 | - |
| CHEMBL287587 | — | — | 1 | - |
| CHEMBL42280 | L-ADRENALINE | — | 1 | - |
| CHEMBL42216 | — | — | 1 | - |
| CHEMBL42370 | — | — | 1 | - |
| CHEMBL295072 | — | — | 1 | - |
| CHEMBL43711 | — | — | 1 | - |
| CHEMBL40593 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL679 | EPINEPHRINE | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL40986 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL679 | EPINEPHRINE | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL40317 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL42359 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL41818 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL59 | DOPAMINE | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL40268 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL295072 | — | Ki | ~ | 25000.0 | nM | - |
| CHEMBL40593 | — | Ki | ~ | 12000.0 | nM | - |
| CHEMBL43711 | — | Ki | ~ | 25000.0 | nM | - |
| CHEMBL295651 | — | Ki | ~ | 40000.0 | nM | - |
| CHEMBL42370 | — | Ki | ~ | 25000.0 | nM | - |
| CHEMBL42216 | — | Ki | ~ | 70000.0 | nM | - |
| CHEMBL42280 | L-ADRENALINE | Ki | ~ | 20000.0 | nM | - |
| CHEMBL287587 | — | Ki | ~ | 50000.0 | nM | - |