Assay Detail
Binding
CHEMBL645550
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Binding affinity towards Alpha-1 adrenergic receptor of rat brain
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.48 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7185 | — | — | 1 | 6.52 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.35 |
| CHEMBL6898 | — | — | 1 | 5.92 |
| CHEMBL268881 | — | — | 1 | 5.17 |
| CHEMBL7681 | — | — | 1 | 5.13 |
| CHEMBL7278 | — | — | 1 | 4.82 |
| CHEMBL266290 | — | — | 1 | 4.44 |
| CHEMBL7160 | — | — | 1 | - |
| CHEMBL6913 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7185 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL6898 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL268881 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL7681 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL7278 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL266290 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL7160 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL6913 | — | Ki | > | 100000.0 | nM | - |