Assay Detail
Binding
CHEMBL645557
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Compound was evaluated for inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat forebrain homogenate.
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
(alpha S)-erythro-alpha-methylepinephrine: preparation and stereoselective binding to adrenergic receptors in rat forebrain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.52 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 6.70 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.30 |
| CHEMBL677 | LEVONORDEFRIN | 4.0 | 3 | 5.44 |
| CHEMBL2114304 | — | — | 1 | 4.96 |
| CHEMBL416557 | DIOXIFEDRINE | 2.0 | 1 | 4.55 |
| CHEMBL23040 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL679 | EPINEPHRINE | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL677 | LEVONORDEFRIN | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL677 | LEVONORDEFRIN | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL2114304 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL416557 | DIOXIFEDRINE | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL677 | LEVONORDEFRIN | Ki | = | 2315000.0 | nM | - |
| CHEMBL23040 | — | Ki | = | 146000.0 | nM | - |