Assay Detail
Binding
CHEMBL645684
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Percent inhibition against binding of [3H]prazosin to cloned mammalian Alpha-1 adrenergic receptor expressed in cultured cells or from rat whole brain at 1 uM
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.66 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81330 | — | — | 1 | 7.42 |
| CHEMBL71724 | — | — | 1 | 5.89 |
| CHEMBL69759 | SONEPIPRAZOLE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81330 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL71724 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL69759 | SONEPIPRAZOLE | Ki | > | 4900.0 | nM | - |