Assay Detail
Binding
CHEMBL645689
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Displacement of [3H]prazosin from Alpha-1 adrenergic receptor of rat cerebral cortex
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
1-(2-METHOXYPHENYL)-4-ALKYLPIPERAZINES: EFFECT OF THE N-4 SUBSTITUENT ON THE AFFINITY AND SELECTIVITY FOR DOPAMINE D4 RECEPTOR
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.45 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26929 | — | — | 1 | 9.00 |
| CHEMBL26758 | — | — | 1 | 8.10 |
| CHEMBL26677 | — | — | 1 | 7.72 |
| CHEMBL26135 | — | — | 1 | 7.39 |
| CHEMBL28209 | — | — | 1 | 7.19 |
| CHEMBL283211 | — | — | 1 | 7.16 |
| CHEMBL28063 | — | — | 1 | 6.90 |
| CHEMBL26426 | — | — | 1 | 6.85 |
| CHEMBL286725 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26929 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL26758 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL26677 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL26135 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL28209 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL283211 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL28063 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL26426 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL286725 | — | Ki | = | 180.0 | nM | 6.75 |