Compound Detail
CHEMBL283211
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Basic Information
| ChEMBL ID | CHEMBL283211 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FQRDAWJJGHRRCG-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
437.6
MW (Da)
3.45
ALogP
5
HBA
1
HBD
54.0
PSA (Ų)
0.64
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL339 | Ki | 7.4 | 7.4 | 40.0 | 1 |
| D(4) dopamine receptor CHEMBL219 | Ki | 7.31 | 7.31 | 49.0 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | Ki | 7.16 | 7.16 | 70.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | Ki | = | 40.0 | nM | 7.4 | Displacement of [3H]spiperone from Dopamine receptor D2 of rat corpora striata s... | - |
| D(4) dopamine receptor | Ki | = | 49.0 | nM | 7.31 | Displacement of [3H]YM-09151-2 from human Dopamine receptor D4.2 expressed in ba... | - |
| Adrenergic receptor alpha-1 | Ki | = | 70.0 | nM | 7.16 | Displacement of [3H]prazosin from Alpha-1 adrenergic receptor of rat cerebral co... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00218-7 | Unchecked | 2 |
| - | 10.1016/S0960-894X(97)00218-7 | D(4) dopamine receptor | 1 |
| - | 10.1016/S0960-894X(97)00218-7 | D(2) dopamine receptor | 1 |
| - | 10.1016/S0960-894X(97)00218-7 | Adrenergic receptor alpha-1 | 1 |
Data from ChEMBL 36 via Core Engine