Assay Detail
Binding
CHEMBL673464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from Dopamine receptor D2 of rat corpora striata synaptic membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-(2-METHOXYPHENYL)-4-ALKYLPIPERAZINES: EFFECT OF THE N-4 SUBSTITUENT ON THE AFFINITY AND SELECTIVITY FOR DOPAMINE D4 RECEPTOR
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.55 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.77 |
| CHEMBL26677 | — | — | 1 | 8.52 |
| CHEMBL28209 | — | — | 1 | 8.30 |
| CHEMBL26929 | — | — | 1 | 8.15 |
| CHEMBL26758 | — | — | 1 | 7.50 |
| CHEMBL283211 | — | — | 1 | 7.40 |
| CHEMBL26135 | — | — | 1 | 7.25 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.93 |
| CHEMBL286725 | — | — | 1 | 6.85 |
| CHEMBL26426 | — | — | 1 | 6.82 |
| CHEMBL28063 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL26677 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL28209 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL26929 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL26758 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL283211 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL26135 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL42 | CLOZAPINE | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL286725 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL26426 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL28063 | — | Ki | = | 253.0 | nM | 6.60 |