Assay Detail
Binding
CHEMBL645693
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The compound was evaluated for the inhibition of [3H]prazosin binding to alpha-1 adrenergic receptor from rat liver
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Conformationally defined adrenergic agents. 2. Catechol imidazoline derivatives: biological effects at alpha 1 and alpha 2 adrenergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.02 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL545092 | — | — | 1 | 6.46 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.41 |
| CHEMBL543684 | — | — | 1 | 6.40 |
| CHEMBL544627 | — | — | 1 | 5.96 |
| CHEMBL554004 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL545092 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL543684 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL544627 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL554004 | — | Ki | = | 13000.0 | nM | 4.89 |