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Assay Detail

CHEMBL646207

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Binding
Inhibition of aminopeptidase A (APA)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Glutamyl aminopeptidase (CHEMBL3439)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols.
Chauvel EN, Llorens-Cortès C, Coric P, Wilk S, Roques BP, Fournié-Zaluski MC.
J Med Chem (1994) 37 : 2950 -2957
PubMed 7915326 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.14 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL101147 1 6.89
CHEMBL28124 1 6.85
CHEMBL102084 1 6.55
CHEMBL100575 1 6.54
CHEMBL330184 1 6.43
CHEMBL441816 1 6.41
CHEMBL103306 1 6.29
CHEMBL103952 1 6.06
CHEMBL102006 1 6.01
CHEMBL100140 1 5.80
CHEMBL317189 1 5.70
CHEMBL101771 1 5.62
CHEMBL103396 1 5.46
CHEMBL317073 1 5.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL101147 Ki = 130.0 nM 6.89
CHEMBL28124 Ki = 140.0 nM 6.85
CHEMBL102084 Ki = 280.0 nM 6.55
CHEMBL100575 Ki = 290.0 nM 6.54
CHEMBL330184 Ki = 370.0 nM 6.43
CHEMBL441816 Ki = 390.0 nM 6.41
CHEMBL103306 Ki = 510.0 nM 6.29
CHEMBL103952 Ki = 870.0 nM 6.06
CHEMBL102006 Ki = 980.0 nM 6.01
CHEMBL100140 Ki = 1600.0 nM 5.80
CHEMBL317189 Ki = 2000.0 nM 5.70
CHEMBL101771 Ki = 2400.0 nM 5.62
CHEMBL103396 Ki = 3500.0 nM 5.46
CHEMBL317073 Ki = 4100.0 nM 5.39