Assay Detail
Binding
CHEMBL646277
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Affinity to Adenosine A2A receptor of rat brain striatum using [3H]-CGS- 21680
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.67 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.42 |
| CHEMBL73809 | — | — | 1 | 5.47 |
| CHEMBL2113388 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL73809 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL2113388 | — | Ki | = | 7400.0 | nM | 5.13 |