Assay Detail
Binding
CHEMBL646376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.45 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558910 | — | — | 1 | 8.66 |
| CHEMBL549577 | — | — | 1 | 8.16 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 8.12 |
| CHEMBL1788199 | — | — | 1 | 6.91 |
| CHEMBL2115342 | — | — | 1 | 6.82 |
| CHEMBL2115341 | — | — | 1 | 5.84 |
| CHEMBL1788286 | — | — | 1 | 5.78 |
| CHEMBL2114395 | — | — | 1 | 4.86 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 4.74 |
| CHEMBL2114396 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558910 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL549577 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL517712 | ATROPINE | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL1788199 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL2115342 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL2115341 | — | Ki | = | 1460.0 | nM | 5.84 |
| CHEMBL1788286 | — | Ki | = | 1660.0 | nM | 5.78 |
| CHEMBL2114395 | — | Ki | = | 13700.0 | nM | 4.86 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 18300.0 | nM | 4.74 |
| CHEMBL2114396 | — | Ki | = | 26700.0 | nM | 4.57 |