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Assay Detail

CHEMBL646403

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Binding
Inhibitory potency was measured on aminopeptidase N (APN)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Aminopeptidase N (CHEMBL2590)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols.
Chauvel EN, Llorens-Cortès C, Coric P, Wilk S, Roques BP, Fournié-Zaluski MC.
J Med Chem (1994) 37 : 2950 -2957
PubMed 7915326 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 5.92 7.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL101771 1 7.50
CHEMBL317189 1 7.43
CHEMBL28124 1 6.92
CHEMBL100140 1 6.55
CHEMBL101147 1 6.48
CHEMBL102084 1 6.22
CHEMBL330184 1 5.72
CHEMBL317073 1 5.55
CHEMBL103306 1 5.43
CHEMBL103952 1 5.40
CHEMBL103396 1 5.35
CHEMBL441816 1 4.92
CHEMBL102006 1 4.81
CHEMBL100575 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL101771 Ki = 32.0 nM 7.50
CHEMBL317189 Ki = 37.0 nM 7.43
CHEMBL28124 Ki = 120.0 nM 6.92
CHEMBL100140 Ki = 280.0 nM 6.55
CHEMBL101147 Ki = 330.0 nM 6.48
CHEMBL102084 Ki = 600.0 nM 6.22
CHEMBL330184 Ki = 1900.0 nM 5.72
CHEMBL317073 Ki = 2800.0 nM 5.55
CHEMBL103306 Ki = 3700.0 nM 5.43
CHEMBL103952 Ki = 4000.0 nM 5.40
CHEMBL103396 Ki = 4500.0 nM 5.35
CHEMBL441816 Ki = 12000.0 nM 4.92
CHEMBL102006 Ki = 15500.0 nM 4.81
CHEMBL100575 Ki = 25000.0 nM 4.60