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Assay Detail

CHEMBL646410

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of pig kidney Aminopeptidase N
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 9 — Direct single protein target
Curated By Expert

Target

Aminopeptidase N (CHEMBL2590)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor.
Chen H, Roques BP, Fournié-Zaluski MC.
Bioorg Med Chem Lett (1999) 9 : 1511 -1516
PubMed 10386926 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.76 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL36661 1 7.96
CHEMBL448735 1 7.66
CHEMBL286865 1 7.60
CHEMBL34963 1 7.57
CHEMBL37279 1 7.55
CHEMBL34907 1 7.52
CHEMBL289824 1 6.89
CHEMBL34068 1 6.72
CHEMBL36716 1 6.43
CHEMBL39753 1 6.40
CHEMBL37846 1 6.02
CHEMBL39768 1 5.92
CHEMBL39977 1 5.32
CHEMBL37702 1 5.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL36661 Ki = 11.0 nM 7.96
CHEMBL448735 Ki = 22.0 nM 7.66
CHEMBL286865 Ki = 25.0 nM 7.60
CHEMBL34963 Ki = 27.0 nM 7.57
CHEMBL37279 Ki = 28.0 nM 7.55
CHEMBL34907 Ki = 30.0 nM 7.52
CHEMBL289824 Ki = 130.0 nM 6.89
CHEMBL34068 Ki = 190.0 nM 6.72
CHEMBL36716 Ki = 370.0 nM 6.43
CHEMBL39753 Ki = 400.0 nM 6.40
CHEMBL37846 Ki = 960.0 nM 6.02
CHEMBL39768 Ki = 1200.0 nM 5.92
CHEMBL39977 Ki = 4800.0 nM 5.32
CHEMBL37702 Ki = 8400.0 nM 5.08