Assay Detail
Binding
CHEMBL647128
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Tested for binding affinity against alpha-1 adrenergic receptor in rat brain using [3H]-Prazosin as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.78 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.35 |
| CHEMBL105434 | — | — | 1 | 4.67 |
| CHEMBL322842 | — | — | 1 | 4.58 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 4.45 |
| CHEMBL99361 | — | — | 1 | 4.38 |
| CHEMBL105383 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL105434 | — | Ki | = | 21500.0 | nM | 4.67 |
| CHEMBL322842 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL434 | ISOPROTERENOL | Ki | = | 35500.0 | nM | 4.45 |
| CHEMBL99361 | — | Ki | = | 42200.0 | nM | 4.38 |
| CHEMBL105383 | — | Ki | = | 60300.0 | nM | 4.22 |