Assay Detail
Binding
CHEMBL647205
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Compound was tested for the inhibition of [3H]clonidine binding Alpha-2 adrenergic receptor of crude rat brain membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
1-(alkylamino)isochromans: hypotensives with peripheral and central activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.25 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 8.77 |
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 8.03 |
| CHEMBL83915 | — | — | 1 | 7.21 |
| CHEMBL160763 | — | — | 1 | 6.51 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134 | CLONIDINE | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL597 | PHENTOLAMINE | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL83915 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL160763 | — | Ki | = | 307.0 | nM | 6.51 |
| CHEMBL2 | PRAZOSIN | Ki | = | 1800.0 | nM | 5.75 |