Assay Detail
Binding
CHEMBL647289
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Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
(Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.65 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340367 | — | — | 1 | 9.33 |
| CHEMBL123084 | — | — | 1 | 9.28 |
| CHEMBL7550 | L-158809 | — | 1 | 9.27 |
| CHEMBL122224 | — | — | 1 | 9.13 |
| CHEMBL122017 | — | — | 1 | 9.12 |
| CHEMBL122212 | — | — | 1 | 9.05 |
| CHEMBL121891 | — | — | 1 | 8.92 |
| CHEMBL332239 | — | — | 1 | 8.55 |
| CHEMBL124541 | — | — | 1 | 8.40 |
| CHEMBL331797 | — | — | 1 | 8.28 |
| CHEMBL122367 | — | — | 1 | 8.17 |
| CHEMBL123562 | — | — | 1 | 7.72 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340367 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL123084 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL7550 | L-158809 | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL122224 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL122017 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL122212 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL121891 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL332239 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL124541 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL331797 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL122367 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL123562 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL191 | LOSARTAN | IC50 | = | 54.0 | nM | 7.27 |