Assay Detail
Binding
CHEMBL647290
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In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Development of angiotensin II antagonists with equipotent affinity for human AT1 and AT2 receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 9.13 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306362 | — | — | 1 | 9.89 |
| CHEMBL311160 | — | — | 1 | 9.72 |
| CHEMBL415073 | — | — | 1 | 9.72 |
| CHEMBL305647 | — | — | 1 | 9.70 |
| CHEMBL74556 | — | — | 1 | 9.64 |
| CHEMBL74476 | — | — | 1 | 9.62 |
| CHEMBL259843 | — | — | 1 | 9.62 |
| CHEMBL263191 | — | — | 1 | 9.28 |
| CHEMBL263452 | — | — | 1 | 9.27 |
| CHEMBL73876 | — | — | 1 | 9.24 |
| CHEMBL74442 | — | — | 1 | 9.21 |
| CHEMBL306361 | — | — | 1 | 9.14 |
| CHEMBL76821 | — | — | 1 | 9.11 |
| CHEMBL307430 | — | — | 1 | 9.04 |
| CHEMBL194608 | — | — | 1 | 8.92 |
| CHEMBL302102 | — | — | 1 | 8.82 |
| CHEMBL17487 | — | — | 1 | 8.70 |
| CHEMBL311386 | — | — | 1 | 8.66 |
| CHEMBL75401 | — | — | 1 | 8.64 |
| CHEMBL305956 | — | — | 1 | 8.64 |
| CHEMBL74144 | — | — | 1 | 8.64 |
| CHEMBL307290 | — | — | 1 | 8.42 |
| CHEMBL311484 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306362 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL311160 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL415073 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL305647 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL74556 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL74476 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL259843 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL263191 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL263452 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL73876 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL74442 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL306361 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL76821 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL307430 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL194608 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL302102 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL17487 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL311386 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL75401 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL305956 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL74144 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL307290 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL311484 | — | IC50 | = | 4.0 | nM | 8.40 |