Assay Detail
Binding
CHEMBL647622
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Binding of [3H]dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes
21
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Syntheses of (R)- and (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: effect of stereochemistry on fluorine-induced adrenergic selectivities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.33 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295072 | — | — | 1 | 6.89 |
| CHEMBL287587 | — | — | 1 | 6.68 |
| CHEMBL42370 | — | — | 1 | 6.25 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 2 | 5.96 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 3 | 5.89 |
| CHEMBL43711 | — | — | 1 | 5.75 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.00 |
| CHEMBL42280 | L-ADRENALINE | — | 1 | 4.89 |
| CHEMBL40268 | — | — | 1 | 4.72 |
| CHEMBL40317 | — | — | 1 | 4.62 |
| CHEMBL41818 | — | — | 1 | 4.39 |
| CHEMBL40796 | — | — | 1 | 4.28 |
| CHEMBL281232 | — | — | 1 | 4.20 |
| CHEMBL42216 | — | — | 1 | - |
| CHEMBL42359 | — | — | 1 | - |
| CHEMBL40986 | — | — | 1 | - |
| CHEMBL295651 | — | — | 1 | - |
| CHEMBL40593 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295072 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL287587 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL42370 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL679 | EPINEPHRINE | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL43711 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL679 | EPINEPHRINE | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL59 | DOPAMINE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL42280 | L-ADRENALINE | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL40268 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL40317 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL41818 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL40796 | — | Ki | = | 52000.0 | nM | 4.28 |
| CHEMBL281232 | — | Ki | = | 63000.0 | nM | 4.20 |
| CHEMBL42359 | — | Ki | ~ | 140000.0 | nM | - |
| CHEMBL42216 | — | Ki | ~ | 400000.0 | nM | - |
| CHEMBL40986 | — | Ki | ~ | 100000.0 | nM | - |
| CHEMBL295651 | — | Ki | ~ | 150000.0 | nM | - |
| CHEMBL40593 | — | Ki | ~ | 120000.0 | nM | - |