Assay Detail
Binding
CHEMBL647623
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Compound was evaluated for beta adrenergic binding affinity towards Beta-1 adrenergic receptor of rat brain
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.89 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.10 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.90 |
| CHEMBL6913 | — | — | 1 | 6.12 |
| CHEMBL7160 | — | — | 1 | 5.10 |
| CHEMBL266290 | — | — | 1 | 4.22 |
| CHEMBL7278 | — | — | 1 | - |
| CHEMBL7185 | — | — | 1 | - |
| CHEMBL6898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL6913 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL7160 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL266290 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL7278 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL7185 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL6898 | — | Ki | > | 100000.0 | nM | - |