Assay Detail
Binding
CHEMBL647629
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Tested for binding affinity against beta-1 adrenergic receptor in rat brain using [3H]-CGP- 26505 as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.70 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.10 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.90 |
| CHEMBL322842 | — | — | 1 | 5.83 |
| CHEMBL105383 | — | — | 1 | 5.46 |
| CHEMBL105434 | — | — | 1 | 4.54 |
| CHEMBL99361 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL322842 | — | Ki | = | 1490.0 | nM | 5.83 |
| CHEMBL105383 | — | Ki | = | 3450.0 | nM | 5.46 |
| CHEMBL105434 | — | Ki | = | 28800.0 | nM | 4.54 |
| CHEMBL99361 | — | Ki | = | 40300.0 | nM | 4.39 |