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Assay Detail

CHEMBL647732

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-CGS- 21680 from Adenosine A2A receptor of rat striatal membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Adenosine receptor A2a (CHEMBL302)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

6-phenyl-1,4-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists.
Jiang JL, van Rhee AM, Melman N, Ji XD, Jacobson KA.
J Med Chem (1996) 39 : 4667 -4675
PubMed 8917655 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 4.85 5.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL108753 1 5.62
CHEMBL337552 1 5.50
CHEMBL315984 1 5.32
CHEMBL99744 1 5.10
CHEMBL142868 1 5.04
CHEMBL100646 1 5.01
CHEMBL105764 1 4.84
CHEMBL143471 1 4.80
CHEMBL419306 1 4.58
CHEMBL325983 1 4.55
CHEMBL100071 1 4.45
CHEMBL140693 1 4.40
CHEMBL103404 1 4.34
CHEMBL2112411 1 4.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL108753 Ki = 2400.0 nM 5.62
CHEMBL337552 Ki = 3150.0 nM 5.50
CHEMBL315984 Ki = 4770.0 nM 5.32
CHEMBL99744 Ki = 7890.0 nM 5.10
CHEMBL142868 Ki = 9230.0 nM 5.04
CHEMBL100646 Ki = 9720.0 nM 5.01
CHEMBL105764 Ki = 14500.0 nM 4.84
CHEMBL143471 Ki = 16000.0 nM 4.80
CHEMBL419306 Ki = 26000.0 nM 4.58
CHEMBL325983 Ki = 28400.0 nM 4.55
CHEMBL100071 Ki = 35900.0 nM 4.45
CHEMBL140693 Ki = 40000.0 nM 4.40
CHEMBL103404 Ki = 46100.0 nM 4.34
CHEMBL2112411 Ki = 49300.0 nM 4.31