Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL647738

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against Adenosine A2A receptor by using [3H]CGS-21680 as radioligand
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Adenosine receptor A2a (CHEMBL302)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor.
van der Wenden EM, von Frijtag Drabbe Künzel JK, Mathôt RA, Danhof M, IJzerman AP, Soudijn W.
J Med Chem (1995) 38 : 4000 -4006
PubMed 7562934 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 5.26 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL139000 (R)-PIA 1 6.85
CHEMBL68738 N6-CYCLOPENTYLADENOSINE 1 6.24
CHEMBL607763 1 5.43
CHEMBL2112569 1 5.13
CHEMBL65976 1 5.07
CHEMBL150197 1 5.00
CHEMBL2112619 1 4.73
CHEMBL2112665 1 4.66
CHEMBL2112664 1 4.24
CHEMBL1790733 1 -
CHEMBL128681 1 -
CHEMBL128173 1 -
CHEMBL1790730 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL139000 (R)-PIA Ki = 140.0 nM 6.85
CHEMBL68738 N6-CYCLOPENTYLADENOSINE Ki = 580.0 nM 6.24
CHEMBL607763 Ki = 3670.0 nM 5.43
CHEMBL2112569 Ki = 7360.0 nM 5.13
CHEMBL65976 Ki = 8600.0 nM 5.07
CHEMBL150197 Ki = 10100.0 nM 5.00
CHEMBL2112619 Ki = 18600.0 nM 4.73
CHEMBL2112665 Ki = 22100.0 nM 4.66
CHEMBL2112664 Ki = 57200.0 nM 4.24
CHEMBL1790733 Ki = 88.0 % -
CHEMBL128681 Ki = 91.0 % -
CHEMBL128173 Ki = 86.0 % -
CHEMBL1790730 Ki = 90.0 % -