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Assay Detail

CHEMBL647874

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Binding
Evaluated for its agonist activity and the binding affinity against human Beta-2 adrenergic receptor in membranes from chinese hamster ovary cell
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type ovary
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Beta-2 adrenergic receptor (CHEMBL210)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties.
Weber AE, Ok HO, Alvaro RF, Candelore MR, Cascieri MA, Chiu SH, Deng L, Forrest MJ, Hom GJ, Hutchins JE, Kao J, MacIntyre DE, Mathvink RJ, McLoughlin D, Miller RR, Newbold RC, Olah TV, Parmee ER, Perkins L, Stearns RA, Strader CD, Szumiloski J, Tang YS, Tota L, Fisher MH.
Bioorg Med Chem Lett (1998) 8 : 2111 -2116
PubMed 9873496 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 6.50 7.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL64201 1 7.55
CHEMBL442172 1 7.30
CHEMBL68021 1 7.03
CHEMBL304878 1 7.00
CHEMBL294042 L-749372 1 6.96
CHEMBL304090 1 6.96
CHEMBL276257 1 6.92
CHEMBL67886 1 6.82
CHEMBL64935 1 6.64
CHEMBL65042 1 6.44
CHEMBL63842 1 6.42
CHEMBL66859 1 6.42
CHEMBL292947 1 6.39
CHEMBL64936 1 6.37
CHEMBL67015 1 6.37
CHEMBL68334 1 6.31
CHEMBL66964 1 6.28
CHEMBL64760 1 6.27
CHEMBL67416 1 6.21
CHEMBL67993 1 6.20
CHEMBL68408 1 6.19
CHEMBL67251 1 6.12
CHEMBL64932 1 6.05
CHEMBL67534 1 6.00
CHEMBL67672 1 6.00
CHEMBL67461 1 5.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL64201 IC50 = 28.0 nM 7.55
CHEMBL442172 IC50 = 50.0 nM 7.30
CHEMBL68021 IC50 = 94.0 nM 7.03
CHEMBL304878 IC50 = 100.0 nM 7.00
CHEMBL294042 L-749372 IC50 = 110.0 nM 6.96
CHEMBL304090 IC50 = 110.0 nM 6.96
CHEMBL276257 IC50 = 120.0 nM 6.92
CHEMBL67886 IC50 = 150.0 nM 6.82
CHEMBL64935 IC50 = 230.0 nM 6.64
CHEMBL65042 IC50 = 360.0 nM 6.44
CHEMBL63842 IC50 = 380.0 nM 6.42
CHEMBL66859 IC50 = 380.0 nM 6.42
CHEMBL292947 IC50 = 410.0 nM 6.39
CHEMBL64936 IC50 = 430.0 nM 6.37
CHEMBL67015 IC50 = 430.0 nM 6.37
CHEMBL68334 IC50 = 490.0 nM 6.31
CHEMBL66964 IC50 = 520.0 nM 6.28
CHEMBL64760 IC50 = 540.0 nM 6.27
CHEMBL67416 IC50 = 620.0 nM 6.21
CHEMBL67993 IC50 = 630.0 nM 6.20
CHEMBL68408 IC50 = 640.0 nM 6.19
CHEMBL67251 IC50 = 750.0 nM 6.12
CHEMBL64932 IC50 = 900.0 nM 6.05
CHEMBL67534 IC50 = 990.0 nM 6.00
CHEMBL67672 IC50 = 1000.0 nM 6.00
CHEMBL67461 IC50 = 1300.0 nM 5.89