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Compound Detail

CHEMBL276257

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O=S(=O)(Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1)c1ccc(I)cc1

Basic Information

ChEMBL ID CHEMBL276257
Phase Preclinical
Structure Type MOL
InChI Key ZNTDIRUBXSTBGJ-NRFANRHFSA-N
3
Targets
7
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

568.4
MW (Da)
3.37
ALogP
6
HBA
4
HBD
107.9
PSA (Ų)
0.21
QED
1
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H25IN2O5S
MW 568.43
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -1.09

Activity Summary

IC50 4 meas. best 6.92
EC50 3 meas. best 8.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.8 8.8 1.6 2
Beta-2 adrenergic receptor
CHEMBL210
IC50 6.92 6.92 120.0 2
Beta-1 adrenergic receptor
CHEMBL213
IC50 6.77 6.77 170.0 2
Beta-1 adrenergic receptor
CHEMBL213
EC50 6.5 6.5 320.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9873496 10.1016/s0960-894x(98)00381-3 Beta-3 adrenergic receptor 2
9871716 10.1016/s0960-894x(98)00169-3 Beta-3 adrenergic receptor 2
9871716 10.1016/s0960-894x(98)00169-3 Beta-1 adrenergic receptor 2
9871716 10.1016/s0960-894x(98)00169-3 Beta-2 adrenergic receptor 2
9873496 10.1016/s0960-894x(98)00381-3 Beta-1 adrenergic receptor 1
9873496 10.1016/s0960-894x(98)00381-3 Beta-2 adrenergic receptor 1
9873496 10.1016/s0960-894x(98)00381-3 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine