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Assay Detail

CHEMBL647879

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against cloned human beta-2 adrenergic receptor from CHO cells using [125I]iodocyanopindolol as the radioligand
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Beta-2 adrenergic receptor (CHEMBL210)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent, selective benzenesulfonamide agonists of the human beta 3 adrenergic receptor.
Weber AE, Mathvink RJ, Perkins L, Hutchins JE, Candelore MR, Tota L, Strader CD, Wyvratt MJ, Fisher MH.
Bioorg Med Chem Lett (1998) 8 : 1101 -1106
PubMed 9871716 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 6.80 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL12994 1 8.00
CHEMBL13102 1 7.96
CHEMBL274782 1 7.70
CHEMBL13079 1 7.68
CHEMBL13238 1 7.24
CHEMBL12762 1 7.20
CHEMBL12633 1 7.08
CHEMBL267306 1 7.00
CHEMBL276257 1 6.92
CHEMBL12674 1 6.92
CHEMBL13003 1 6.89
CHEMBL12876 1 6.82
CHEMBL12718 1 6.77
CHEMBL267545 1 6.75
CHEMBL417613 1 6.72
CHEMBL12686 1 6.72
CHEMBL12188 1 6.66
CHEMBL276659 1 6.64
CHEMBL12769 1 6.62
CHEMBL12498 1 6.60
CHEMBL12450 1 6.55
CHEMBL12813 1 6.43
CHEMBL276480 1 6.30
CHEMBL13034 1 6.30
CHEMBL13278 1 6.20
CHEMBL274807 1 5.52
CHEMBL12945 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL12994 IC50 = 10.0 nM 8.00
CHEMBL13102 IC50 = 11.0 nM 7.96
CHEMBL274782 IC50 = 20.0 nM 7.70
CHEMBL13079 IC50 = 21.0 nM 7.68
CHEMBL13238 IC50 = 58.0 nM 7.24
CHEMBL12762 IC50 = 63.0 nM 7.20
CHEMBL12633 IC50 = 84.0 nM 7.08
CHEMBL267306 IC50 = 100.0 nM 7.00
CHEMBL276257 IC50 = 120.0 nM 6.92
CHEMBL12674 IC50 = 120.0 nM 6.92
CHEMBL13003 IC50 = 130.0 nM 6.89
CHEMBL12876 IC50 = 150.0 nM 6.82
CHEMBL12718 IC50 = 170.0 nM 6.77
CHEMBL267545 IC50 = 180.0 nM 6.75
CHEMBL417613 IC50 = 190.0 nM 6.72
CHEMBL12686 IC50 = 190.0 nM 6.72
CHEMBL12188 IC50 = 220.0 nM 6.66
CHEMBL276659 IC50 = 230.0 nM 6.64
CHEMBL12769 IC50 = 240.0 nM 6.62
CHEMBL12498 IC50 = 250.0 nM 6.60
CHEMBL12450 IC50 = 280.0 nM 6.55
CHEMBL12813 IC50 = 370.0 nM 6.43
CHEMBL276480 IC50 = 500.0 nM 6.30
CHEMBL13034 IC50 = 500.0 nM 6.30
CHEMBL13278 IC50 = 630.0 nM 6.20
CHEMBL274807 IC50 = 3000.0 nM 5.52
CHEMBL12945 IC50 = 3000.0 nM 5.52