Assay Detail
Binding
CHEMBL649968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated for its agonist activity and the binding affinity against human Beta-1 adrenergic receptor in membranes from chinese hamster ovary cell
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | ovary |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.96 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442172 | — | — | 1 | 7.10 |
| CHEMBL276257 | — | — | 1 | 6.77 |
| CHEMBL65042 | — | — | 1 | 6.54 |
| CHEMBL304090 | — | — | 1 | 6.36 |
| CHEMBL66859 | — | — | 1 | 6.33 |
| CHEMBL68021 | — | — | 1 | 6.23 |
| CHEMBL67015 | — | — | 1 | 6.22 |
| CHEMBL67886 | — | — | 1 | 6.07 |
| CHEMBL68408 | — | — | 1 | 6.05 |
| CHEMBL304878 | — | — | 1 | 6.04 |
| CHEMBL64932 | — | — | 1 | 6.00 |
| CHEMBL64936 | — | — | 1 | 6.00 |
| CHEMBL64201 | — | — | 1 | 6.00 |
| CHEMBL292947 | — | — | 1 | 6.00 |
| CHEMBL66964 | — | — | 1 | 6.00 |
| CHEMBL294042 | L-749372 | — | 1 | 6.00 |
| CHEMBL67251 | — | — | 1 | 5.89 |
| CHEMBL68334 | — | — | 1 | 5.89 |
| CHEMBL64760 | — | — | 1 | 5.75 |
| CHEMBL67672 | — | — | 1 | 5.70 |
| CHEMBL64935 | — | — | 1 | 5.70 |
| CHEMBL67534 | — | — | 1 | 5.70 |
| CHEMBL63842 | — | — | 1 | 5.28 |
| CHEMBL67416 | — | — | 1 | 5.26 |
| CHEMBL67461 | — | — | 1 | 5.20 |
| CHEMBL67993 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442172 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL276257 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL65042 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL304090 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL66859 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL68021 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL67015 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL67886 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL68408 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL304878 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL64932 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL64936 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL64201 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL292947 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL66964 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL294042 | L-749372 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL67251 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL68334 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL64760 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL67672 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL64935 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL67534 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL63842 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL67416 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL67461 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL67993 | — | IC50 | = | 10000.0 | nM | 5.00 |