Assay Detail
Binding
CHEMBL647889
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Inhibitory activity against Angiotensin II receptor type 1 in rat adrenal membrane
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.89 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76525 | — | — | 1 | 9.32 |
| CHEMBL307844 | — | — | 1 | 9.24 |
| CHEMBL291582 | — | — | 1 | 8.68 |
| CHEMBL443269 | — | — | 1 | 8.51 |
| CHEMBL115021 | — | — | 1 | 8.22 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.72 |
| CHEMBL262958 | — | — | 1 | 6.92 |
| CHEMBL274447 | — | — | 1 | 6.64 |
| CHEMBL25686 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76525 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL307844 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL291582 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL443269 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL115021 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL191 | LOSARTAN | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL262958 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL274447 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL25686 | — | IC50 | = | 1600.0 | nM | 5.80 |