Compound Detail
CHEMBL307844
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CCCc1nc(-n2cccc2C(=O)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
Basic Information
| ChEMBL ID | CHEMBL307844 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MGSBGAVGFLLRDU-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
549.5
MW (Da)
4.96
ALogP
8
HBA
2
HBD
131.6
PSA (Ų)
0.25
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin II receptor (AT-1) type-1 CHEMBL2094250 | IC50 | 9.24 | 9.24 | 0.6 | 2 |
| Unchecked CHEMBL612545 | IC50 | 9.1 | 9.1 | 0.8 | 1 |
| Angiotensin II receptor CHEMBL2094256 | IC50 | 8.42 | 8.42 | 3.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin II receptor (AT-1) type-1 | IC50 | = | 0.58 | nM | 9.24 | Inhibitory concentration against binding of [125I]angiotensin II to rat liver ex... | 8360871 |
| Angiotensin II receptor (AT-1) type-1 | IC50 | = | 0.58 | nM | 9.24 | Inhibitory activity against Angiotensin II receptor type 1 in rat adrenal membra... | 8576904 |
| Unchecked | IC50 | = | 0.8 | nM | 9.1 | Displacement of [125I]-angiotensin 2 from angiotensin AT1 receptor in rat liver ... | 21071232 |
| Angiotensin II receptor | IC50 | = | 3.8 | nM | 8.42 | Inhibitory concentration against [125I]angiotensin II(AII) induced contraction i... | 8360871 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8360871 | 10.1021/jm00068a002 | Rattus norvegicus | 2 |
| 8360871 | 10.1021/jm00068a002 | Angiotensin II receptor (AT-1) type-1 | 1 |
| 8360871 | 10.1021/jm00068a002 | Angiotensin II receptor | 1 |
| 8576904 | 10.1021/jm9504722 | Angiotensin II receptor (AT-1) type-1 | 1 |
| 21071232 | 10.1016/j.bmc.2010.10.043 | Unchecked | 1 |
| 21071232 | 10.1016/j.bmc.2010.10.043 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine