Assay Detail
Binding
CHEMBL647924
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Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Discovery of a novel class of orally active, non-peptide angiotensin II antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 9.46 | 9.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333534 | — | — | 1 | 9.93 |
| CHEMBL421473 | — | — | 1 | 9.60 |
| CHEMBL125218 | — | — | 1 | 9.50 |
| CHEMBL124772 | — | — | 1 | 8.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333534 | — | Kd | = | 0.1175 | nM | 9.93 |
| CHEMBL421473 | — | Kd | = | 0.2512 | nM | 9.60 |
| CHEMBL125218 | — | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL124772 | — | Kd | = | 1.549 | nM | 8.81 |