Assay Detail
Binding
CHEMBL647932
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Competitive inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver; Ki value reporting the slope effect(Kis)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.28 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28623 | — | — | 1 | 8.40 |
| CHEMBL140459 | — | — | 1 | 6.77 |
| CHEMBL2114365 | — | — | 1 | 6.11 |
| CHEMBL282212 | — | — | 1 | 5.70 |
| CHEMBL284228 | — | — | 1 | 4.44 |
| CHEMBL27690 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28623 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL140459 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL2114365 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL282212 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL284228 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL27690 | — | Ki | = | 130000.0 | nM | - |