Assay Detail
Binding
CHEMBL647962
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Binding affinity for human Alpha-2A adrenergic receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.47 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 8.42 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 7.18 |
| CHEMBL19236 | MOXONIDINE | 4.0 | 1 | 6.82 |
| CHEMBL430112 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134 | CLONIDINE | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL19236 | MOXONIDINE | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL430112 | — | Ki | > | 20000.0 | nM | - |