Assay Detail
Binding
CHEMBL648048
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In vitro binding affinity at Alpha-1 adrenergic receptor by radioligand binding assay using [3H]prazosin
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of ABT-200: a putative novel antidepressant combining potent -2 antagonism with moderate NE uptake inhibition
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.97 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 7.34 |
| CHEMBL25014 | — | — | 1 | 7.32 |
| CHEMBL27926 | NAPITANE | 2.0 | 3 | 7.12 |
| CHEMBL285367 | — | — | 1 | 6.98 |
| CHEMBL433033 | — | — | 1 | 6.72 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11 | IMIPRAMINE | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL25014 | — | Ki | = | 47.4 | nM | 7.32 |
| CHEMBL27926 | NAPITANE | Ki | = | 75.9 | nM | 7.12 |
| CHEMBL285367 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL27926 | NAPITANE | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL27926 | NAPITANE | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL433033 | — | Ki | = | 189.0 | nM | 6.72 |
| CHEMBL10316 | IDAZOXAN | Ki | = | 403.0 | nM | 6.39 |