Assay Detail
Binding
CHEMBL648136
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Binding affinity to peripheral benzodiazepine receptors using [3H]-PK11195 radioligand in rat kidney mitochondrial membrane
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.96 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53430 | — | — | 1 | 9.43 |
| CHEMBL55162 | — | — | 1 | 9.26 |
| CHEMBL55781 | — | — | 1 | 9.21 |
| CHEMBL292847 | — | — | 1 | 9.00 |
| CHEMBL294625 | — | — | 1 | 8.85 |
| CHEMBL55135 | — | — | 1 | 8.80 |
| CHEMBL300762 | — | — | 1 | 8.72 |
| CHEMBL54403 | — | — | 1 | 8.62 |
| CHEMBL54627 | — | — | 1 | 8.55 |
| CHEMBL431747 | — | — | 1 | 8.42 |
| CHEMBL299487 | — | — | 1 | 8.37 |
| CHEMBL294423 | — | — | 1 | 8.33 |
| CHEMBL54066 | — | — | 1 | 8.31 |
| CHEMBL53255 | — | — | 1 | 8.26 |
| CHEMBL53259 | — | — | 1 | 8.24 |
| CHEMBL54349 | ALPIDEM | 4.0 | 1 | 8.15 |
| CHEMBL431938 | — | — | 1 | 8.12 |
| CHEMBL481537 | PK-11195 | — | 1 | 8.03 |
| CHEMBL56058 | — | — | 1 | 7.91 |
| CHEMBL291774 | — | — | 1 | 7.80 |
| CHEMBL55190 | — | — | 1 | 7.77 |
| CHEMBL286346 | RO-54864 | — | 1 | 7.64 |
| CHEMBL54740 | — | — | 1 | 7.48 |
| CHEMBL55126 | — | — | 1 | 7.37 |
| CHEMBL300128 | — | — | 1 | 7.23 |
| CHEMBL301836 | — | — | 1 | 6.99 |
| CHEMBL299975 | — | — | 1 | 6.18 |
| CHEMBL53277 | — | — | 1 | 6.09 |
| CHEMBL55316 | — | — | 1 | 5.93 |
| CHEMBL55648 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53430 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL55162 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL55781 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL292847 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL294625 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL55135 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL300762 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL54403 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL54627 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL431747 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL299487 | — | Ki | = | 4.28 | nM | 8.37 |
| CHEMBL294423 | — | Ki | = | 4.65 | nM | 8.33 |
| CHEMBL54066 | — | Ki | = | 4.91 | nM | 8.31 |
| CHEMBL53255 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL53259 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL54349 | ALPIDEM | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL431938 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL481537 | PK-11195 | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL56058 | — | Ki | = | 12.2 | nM | 7.91 |
| CHEMBL291774 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL55190 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL286346 | RO-54864 | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL54740 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL55126 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL300128 | — | Ki | = | 58.4 | nM | 7.23 |
| CHEMBL301836 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL299975 | — | Ki | = | 665.0 | nM | 6.18 |
| CHEMBL53277 | — | Ki | = | 815.0 | nM | 6.09 |
| CHEMBL55316 | — | Ki | = | 1167.0 | nM | 5.93 |
| CHEMBL55648 | — | Ki | = | 2400.0 | nM | 5.62 |