Assay Detail
Functional
CHEMBL648426
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective dose for contraction of reserpine-pretreated rat vas deferens.
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.43 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL677 | LEVONORDEFRIN | 4.0 | 1 | 6.11 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 2 | 5.39 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL677 | LEVONORDEFRIN | EC50 | = | 776.0 | nM | 6.11 |
| CHEMBL679 | EPINEPHRINE | EC50 | = | 4073.0 | nM | 5.39 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL679 | EPINEPHRINE | EC50 | > | 100000.0 | nM | - |