Assay Detail
Binding
CHEMBL648484
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against angiotensin I converting enzyme of rats.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 8.09 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277976 | — | — | 1 | 8.70 |
| CHEMBL16190 | — | — | 1 | 8.70 |
| CHEMBL279763 | — | — | 1 | 8.70 |
| CHEMBL16163 | — | — | 1 | 8.70 |
| CHEMBL579 | SPIRAPRILAT | 2.0 | 1 | 8.70 |
| CHEMBL15954 | — | — | 1 | 8.70 |
| CHEMBL16138 | — | — | 1 | 8.55 |
| CHEMBL279566 | — | — | 1 | 8.54 |
| CHEMBL277951 | — | — | 1 | 8.52 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.40 |
| CHEMBL417810 | — | — | 1 | 8.30 |
| CHEMBL277074 | — | — | 1 | 8.30 |
| CHEMBL15879 | — | — | 1 | 8.30 |
| CHEMBL16139 | — | — | 1 | 8.19 |
| CHEMBL276104 | — | — | 1 | 8.14 |
| CHEMBL16332 | ZOFENOPRILAT | 2.0 | 1 | 8.10 |
| CHEMBL417994 | — | — | 1 | 8.07 |
| CHEMBL276505 | — | — | 1 | 7.96 |
| CHEMBL15424 | — | — | 1 | 7.92 |
| CHEMBL15775 | — | — | 1 | 7.89 |
| CHEMBL276103 | — | — | 1 | 7.80 |
| CHEMBL16166 | — | — | 1 | 7.77 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.64 |
| CHEMBL278428 | — | — | 1 | 7.58 |
| CHEMBL15777 | — | — | 1 | 7.55 |
| CHEMBL15977 | — | — | 1 | 7.52 |
| CHEMBL279154 | — | — | 1 | 7.34 |
| CHEMBL274988 | — | — | 1 | 7.02 |
| CHEMBL278427 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277976 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL16190 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL279763 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL16163 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL579 | SPIRAPRILAT | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL15954 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL16138 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL279566 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL277951 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL417810 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL277074 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL15879 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL16139 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL276104 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL16332 | ZOFENOPRILAT | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL417994 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL276505 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL15424 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL15775 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL276103 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL16166 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL278428 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL15777 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL15977 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL279154 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL274988 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL278427 | — | IC50 | = | 97.0 | nM | 7.01 |