Compound Detail
CHEMBL16332
ZOFENOPRILAT 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL16332 |
| Name | ZOFENOPRILAT |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | UQWLOWFDKAFKAP-WXHSDQCUSA-N |
2
Targets
2
Activities
2
Assay Types
1
PK Parameters
3
Publications
1
Known Names
Molecular Properties
325.4
MW (Da)
2.40
ALogP
4
HBA
2
HBD
57.6
PSA (Ų)
0.82
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 1 meas. best 8.1
Ki 1 meas. best 9.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme CHEMBL4074 | Ki | 9.4 | 9.4 | 0.4 | 1 |
| Angiotensin-converting enzyme CHEMBL2625 | IC50 | 8.1 | 8.1 | 8.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | 79.0 | % | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | Ki | = | 0.4 | nM | 9.4 | Inhibitory constant against rabbit lung Angiotensin I converting enzyme | 2836590 |
| Angiotensin-converting enzyme | IC50 | = | 8.0 | nM | 8.1 | In vitro inhibitory activity against angiotensin I converting enzyme of rats. | 2836590 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2836590 | 10.1021/jm00401a014 | Angiotensin-converting enzyme | 2 |
| 10891117 | 10.1021/jm0000564 | No relevant target | 2 |
| 10891117 | 10.1021/jm0000564 | ADMET | 2 |
Data from ChEMBL 36 via Core Engine