Assay Detail
Functional
CHEMBL648807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against postsynaptic alpha-1 adrenergic receptor in rabbit pulmonary artery using l-norepinephrine as agonist
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Pulmonary artery |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Berbanes: a new class of selective alpha 2-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 6.45 | 8.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 8.76 |
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 7.82 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 6.85 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 6.83 |
| CHEMBL281708 | — | — | 1 | 6.19 |
| CHEMBL28531 | — | — | 1 | 5.39 |
| CHEMBL29379 | — | — | 1 | 4.98 |
| CHEMBL282636 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Kd | = | 1.738 | nM | 8.76 |
| CHEMBL597 | PHENTOLAMINE | Kd | = | 15.14 | nM | 7.82 |
| CHEMBL10316 | IDAZOXAN | Kd | = | 141.25 | nM | 6.85 |
| CHEMBL15245 | YOHIMBINE | Kd | = | 147.91 | nM | 6.83 |
| CHEMBL281708 | — | Kd | = | 645.65 | nM | 6.19 |
| CHEMBL28531 | — | Kd | = | 4073.8 | nM | 5.39 |
| CHEMBL29379 | — | Kd | = | 10471.29 | nM | 4.98 |
| CHEMBL282636 | — | Kd | = | 15488.17 | nM | 4.81 |