Assay Detail
Binding
CHEMBL648844
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
98
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 98 | 7.16 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7550 | L-158809 | — | 1 | 9.52 |
| CHEMBL352236 | — | — | 1 | 8.85 |
| CHEMBL157577 | — | — | 1 | 8.82 |
| CHEMBL345459 | — | — | 1 | 8.52 |
| CHEMBL345570 | — | — | 1 | 8.48 |
| CHEMBL156934 | — | — | 1 | 8.39 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | — | 1 | 8.22 |
| CHEMBL347404 | — | — | 1 | 8.21 |
| CHEMBL346542 | — | — | 1 | 8.18 |
| CHEMBL155877 | — | — | 1 | 8.17 |
| CHEMBL347135 | — | — | 1 | 8.17 |
| CHEMBL345717 | — | — | 1 | 8.15 |
| CHEMBL158133 | — | — | 1 | 8.13 |
| CHEMBL345139 | — | — | 1 | 8.12 |
| CHEMBL345404 | — | — | 1 | 8.11 |
| CHEMBL434844 | — | — | 1 | 8.05 |
| CHEMBL348143 | — | — | 1 | 8.00 |
| CHEMBL155638 | — | — | 1 | 7.96 |
| CHEMBL157980 | — | — | 1 | 7.89 |
| CHEMBL156084 | — | — | 1 | 7.85 |
| CHEMBL155948 | — | — | 1 | 7.85 |
| CHEMBL155661 | — | — | 1 | 7.82 |
| CHEMBL352235 | — | — | 1 | 7.82 |
| CHEMBL422333 | — | — | 1 | 7.77 |
| CHEMBL157690 | — | — | 1 | 7.70 |
| CHEMBL157524 | — | — | 1 | 7.68 |
| CHEMBL155008 | — | — | 1 | 7.62 |
| CHEMBL347392 | — | — | 1 | 7.62 |
| CHEMBL157620 | — | — | 1 | 7.58 |
| CHEMBL157779 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7550 | L-158809 | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL352236 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL157577 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL345459 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL345570 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL156934 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL347404 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL346542 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL155877 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL347135 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL345717 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL158133 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL345139 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL345404 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL434844 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL348143 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL155638 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL157980 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL156084 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL155948 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL155661 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL352235 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL422333 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL157690 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL157524 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL347392 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL155008 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL157620 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL157779 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL155554 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL158257 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL423233 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL157878 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL348606 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL155984 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL154027 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL155035 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL158267 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL346145 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL158115 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL157185 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL347630 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL348568 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL191 | LOSARTAN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL345826 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL350241 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL155305 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL157512 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL153968 | — | IC50 | = | 60.0 | nM | 7.22 |