Assay Detail
Binding
CHEMBL648849
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Evaluation of heterocyclic acid equivalents as tetrazole replacements in imidazopyridine-based nonpeptide angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.78 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7550 | L-158809 | — | 1 | 9.52 |
| CHEMBL344407 | — | — | 1 | 9.15 |
| CHEMBL87842 | — | — | 1 | 8.42 |
| CHEMBL424289 | — | — | 1 | 8.22 |
| CHEMBL138358 | — | — | 1 | 8.19 |
| CHEMBL441837 | — | — | 1 | 7.96 |
| CHEMBL139739 | — | — | 1 | 7.24 |
| CHEMBL337787 | — | — | 1 | 6.92 |
| CHEMBL344388 | — | — | 1 | 6.26 |
| CHEMBL136911 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7550 | L-158809 | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL344407 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL87842 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL424289 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL138358 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL441837 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL139739 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL337787 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL344388 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL136911 | — | IC50 | = | 1300.0 | nM | 5.89 |