Assay Detail
Binding
CHEMBL648850
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Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Acidic phenols: a new class of potent nonpeptide angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.14 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7550 | L-158809 | — | 1 | 9.52 |
| CHEMBL303147 | — | — | 1 | 8.30 |
| CHEMBL291358 | — | — | 1 | 8.22 |
| CHEMBL64983 | — | — | 1 | 8.10 |
| CHEMBL293926 | — | — | 1 | 7.96 |
| CHEMBL63144 | — | — | 1 | 7.80 |
| CHEMBL303186 | — | — | 1 | 7.66 |
| CHEMBL63879 | — | — | 1 | 7.60 |
| CHEMBL67616 | — | — | 1 | 7.50 |
| CHEMBL63280 | — | — | 1 | 7.29 |
| CHEMBL293846 | — | — | 1 | 6.80 |
| CHEMBL304655 | — | — | 1 | 6.60 |
| CHEMBL292739 | — | — | 1 | 6.48 |
| CHEMBL67309 | — | — | 1 | 6.39 |
| CHEMBL68111 | — | — | 1 | 6.36 |
| CHEMBL277614 | — | — | 1 | 6.11 |
| CHEMBL304116 | — | — | 1 | 6.07 |
| CHEMBL302869 | — | — | 1 | 5.96 |
| CHEMBL66056 | — | — | 1 | 4.96 |
| CHEMBL63250 | — | — | 1 | - |
| CHEMBL63220 | — | — | 1 | - |
| CHEMBL293925 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7550 | L-158809 | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL303147 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL291358 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL64983 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL293926 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL63144 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL303186 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL63879 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL67616 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL63280 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL293846 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL304655 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL292739 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL67309 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL68111 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL277614 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL304116 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL302869 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL66056 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL63250 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL63220 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL293925 | — | IC50 | > | 1200.0 | nM | - |