Assay Detail
Binding
CHEMBL648853
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Angiotensin II receptor antagonists containing a phenylpyridine element.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.17 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7550 | L-158809 | — | 1 | 9.30 |
| CHEMBL296725 | — | — | 1 | 9.00 |
| CHEMBL47382 | — | — | 1 | 8.40 |
| CHEMBL47459 | — | — | 1 | 7.22 |
| CHEMBL410939 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7550 | L-158809 | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL296725 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL47382 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL47459 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL410939 | — | IC50 | = | 116.0 | nM | 6.94 |